Assay Detail
Binding
CHEMBL2344119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AMPK A1/B1/G1 (unknown origin) by FRET-based Z'-LYTE assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 (CHEMBL2111345) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.06 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574646 | — | — | 1 | 5.82 |
| CHEMBL2338333 | — | — | 1 | 5.60 |
| CHEMBL2338335 | — | — | 1 | 5.00 |
| CHEMBL2338334 | — | — | 1 | 5.00 |
| CHEMBL2036343 | — | — | 1 | 4.58 |
| CHEMBL379849 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574646 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2338333 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2338335 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2338334 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2036343 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL379849 | — | IC50 | = | 46000.0 | nM | 4.34 |