Assay Detail
Binding
CHEMBL2344121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKT2 (unknown origin) by FRET-based Z'-LYTE assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.26 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574646 | — | — | 1 | 7.70 |
| CHEMBL379849 | — | — | 1 | 6.14 |
| CHEMBL2338333 | — | — | 1 | 5.72 |
| CHEMBL2036343 | — | — | 1 | 5.48 |
| CHEMBL2338335 | — | — | 1 | - |
| CHEMBL2338334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574646 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL379849 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2338333 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2036343 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2338335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2338334 | — | IC50 | > | 100000.0 | nM | - |