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Assay Detail

CHEMBL2344176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MRC5 cells after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Antiproliferative withanolides from Datura wrightii.
Zhang H, Bazzill J, Gallagher RJ, Subramanian C, Grogan PT, Day VW, Kindscher K, Cohen MS, Timmermann BN.
J Nat Prod (2013) 76 : 445 -449
PubMed 23252848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 5.57 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL517080 WITHAFERIN A 1.0 1 6.70
CHEMBL2333592 WITHAMETELIN F 1 5.48
CHEMBL2333166 WITHAMETELIN L 1 5.38
CHEMBL2333591 WITHAMETELIN O 1 5.34
CHEMBL2333167 WITHAMETELIN 1 5.29
CHEMBL2333165 WITHAWRIGHTOLIDE 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL517080 WITHAFERIN A IC50 = 200.0 nM 6.70
CHEMBL2333592 WITHAMETELIN F IC50 = 3300.0 nM 5.48
CHEMBL2333166 WITHAMETELIN L IC50 = 4200.0 nM 5.38
CHEMBL2333591 WITHAMETELIN O IC50 = 4600.0 nM 5.34
CHEMBL2333167 WITHAMETELIN IC50 = 5100.0 nM 5.29
CHEMBL2333165 WITHAWRIGHTOLIDE IC50 = 5600.0 nM 5.25