Assay Detail
Functional
CHEMBL2344483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H] hypoxanthine uptake by liquid scintillation counting
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.92 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2331691 | — | — | 1 | 7.11 |
| CHEMBL2331631 | — | — | 1 | 7.00 |
| CHEMBL2331633 | — | — | 1 | 6.79 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.67 |
| CHEMBL99254 | — | — | 1 | 6.53 |
| CHEMBL2331692 | — | — | 1 | 6.41 |
| CHEMBL2331632 | — | — | 1 | 6.31 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 6.19 |
| CHEMBL2331690 | — | — | 1 | 6.01 |
| CHEMBL460418 | — | — | 1 | 5.96 |
| CHEMBL31000 | — | — | 1 | 5.83 |
| CHEMBL2331634 | — | — | 1 | 5.69 |
| CHEMBL2331697 | — | — | 1 | 5.10 |
| CHEMBL2331698 | — | — | 1 | 5.06 |
| CHEMBL2331693 | — | — | 1 | 4.98 |
| CHEMBL2331696 | — | — | 1 | 4.80 |
| CHEMBL2331695 | — | — | 1 | 4.20 |
| CHEMBL2331694 | — | — | 1 | - |
| CHEMBL489704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2331691 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2331631 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2331633 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL99254 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL2331692 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL2331632 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL2331690 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL460418 | — | IC50 | = | 1086.0 | nM | 5.96 |
| CHEMBL31000 | — | IC50 | = | 1468.0 | nM | 5.83 |
| CHEMBL2331634 | — | IC50 | = | 2042.0 | nM | 5.69 |
| CHEMBL2331697 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL2331698 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL2331693 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL2331696 | — | IC50 | = | 15790.0 | nM | 4.80 |
| CHEMBL2331695 | — | IC50 | = | 62620.0 | nM | 4.20 |
| CHEMBL2331694 | — | IC50 | - | — | - | |
| CHEMBL489704 | — | IC50 | > | 270000.0 | nM | - |