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Assay Detail

CHEMBL2344590

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PC3 cells after 72 hrs by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro.
Tronina T, Bartmańska A, Filip-Psurska B, Wietrzyk J, Popłoński J, Huszcza E.
Bioorg Med Chem (2013) 21 : 2001 -2006
PubMed 23434138 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.45 4.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL253896 XANTHOHUMOL 2.0 1 4.97
CHEMBL510279 DIHYDROXANTHOHUMOL 1 4.83
CHEMBL479500 XANTHOHUMOL D 1 4.42
CHEMBL2337359 1 4.19
CHEMBL2337358 1 4.16
CHEMBL492828 ISOXANTHOHUMOL 1 4.15
CHEMBL2337361 1 -
CHEMBL2337360 1 -
CHEMBL470927 XANTHOHUMOL H 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL253896 XANTHOHUMOL IC50 = 10670.0 nM 4.97
CHEMBL510279 DIHYDROXANTHOHUMOL IC50 = 14730.0 nM 4.83
CHEMBL479500 XANTHOHUMOL D IC50 = 37880.0 nM 4.42
CHEMBL2337359 IC50 = 64550.0 nM 4.19
CHEMBL2337358 IC50 = 69250.0 nM 4.16
CHEMBL492828 ISOXANTHOHUMOL IC50 = 71320.0 nM 4.15
CHEMBL2337361 IC50 = 117250.0 nM -
CHEMBL2337360 IC50 = 141870.0 nM -
CHEMBL470927 XANTHOHUMOL H IC50 - -