Assay Detail
Binding
CHEMBL2344599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-9-cis-RA from RXRalpha (unknown origin) by liquid scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.85 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337793 | — | — | 1 | 5.62 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337793 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL15770 | SULINDAC | IC50 | = | 82900.0 | nM | 4.08 |