Assay Detail
Binding
CHEMBL2344627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cyp11B2 transfected in chinese hamster V79MZ cells using deoxycorticosterone as substrate incubated for 60 mins prior to substrate addition measured after 50 mins by HPLC analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aldosterone synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2331704 | — | — | 1 | 8.30 |
| CHEMBL2331706 | — | — | 1 | 8.30 |
| CHEMBL2331701 | — | — | 1 | 7.77 |
| CHEMBL2331705 | — | — | 1 | 7.66 |
| CHEMBL2331702 | — | — | 1 | 7.50 |
| CHEMBL2331700 | — | — | 1 | 7.39 |
| CHEMBL2331703 | — | — | 1 | 7.32 |
| CHEMBL2331699 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2331704 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2331706 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2331701 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2331705 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2331702 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2331700 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2331703 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2331699 | — | IC50 | = | 89.0 | nM | 7.05 |