Assay Detail
Binding
CHEMBL2344635
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Inhibition of Lck (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.00 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566515 | — | — | 1 | 8.89 |
| CHEMBL2333602 | — | — | 1 | 6.58 |
| CHEMBL2333603 | — | — | 1 | 6.31 |
| CHEMBL2333595 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566515 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2333602 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL2333603 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL2333595 | — | IC50 | = | 617.0 | nM | 6.21 |