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Assay Detail

CHEMBL2344656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-MC cells measured after 72 hrs at 37 degC by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy.
Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR.
Bioorg Med Chem Lett (2013) 23 : 967 -974
PubMed 23312948 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.12 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL385064 1 8.40
CHEMBL2333187 1 8.05
CHEMBL2333194 1 6.21
CHEMBL2333185 1 6.06
CHEMBL2333200 1 5.76
CHEMBL2333199 1 5.66
CHEMBL2333193 1 5.61
CHEMBL2333188 1 5.55
CHEMBL2333184 1 5.27
CHEMBL556 DEFEROXAMINE 4.0 1 4.67
CHEMBL2333197 1 -
CHEMBL2333196 1 -
CHEMBL2333195 1 -
CHEMBL2333192 1 -
CHEMBL2333191 1 -
CHEMBL2333190 1 -
CHEMBL2333189 1 -
CHEMBL2333186 1 -
CHEMBL2333183 1 -
CHEMBL2333198 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL385064 IC50 = 4.0 nM 8.40
CHEMBL2333187 IC50 = 9.0 nM 8.05
CHEMBL2333194 IC50 = 620.0 nM 6.21
CHEMBL2333185 IC50 = 880.0 nM 6.06
CHEMBL2333200 IC50 = 1750.0 nM 5.76
CHEMBL2333199 IC50 = 2200.0 nM 5.66
CHEMBL2333193 IC50 = 2480.0 nM 5.61
CHEMBL2333188 IC50 = 2800.0 nM 5.55
CHEMBL2333184 IC50 = 5320.0 nM 5.27
CHEMBL556 DEFEROXAMINE IC50 = 21630.0 nM 4.67
CHEMBL2333197 IC50 > 6250.0 nM -
CHEMBL2333196 IC50 > 6250.0 nM -
CHEMBL2333195 IC50 > 6250.0 nM -
CHEMBL2333192 IC50 > 6250.0 nM -
CHEMBL2333191 IC50 > 6250.0 nM -
CHEMBL2333190 IC50 > 6250.0 nM -
CHEMBL2333189 IC50 > 6250.0 nM -
CHEMBL2333186 IC50 > 6250.0 nM -
CHEMBL2333183 IC50 > 6250.0 nM -
CHEMBL2333198 IC50 > 6250.0 nM -