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Assay Detail

CHEMBL2344657

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Functional
Antiproliferative activity against human MRC5 cells measured after 72 hrs at 37 degC by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy.
Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR.
Bioorg Med Chem Lett (2013) 23 : 967 -974
PubMed 23312948 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.26 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333187 1 7.68
CHEMBL2333194 1 5.68
CHEMBL2333200 1 5.42
CHEMBL2333198 1 -
CHEMBL2333197 1 -
CHEMBL2333196 1 -
CHEMBL2333195 1 -
CHEMBL2333193 1 -
CHEMBL2333192 1 -
CHEMBL2333191 1 -
CHEMBL2333190 1 -
CHEMBL2333199 1 -
CHEMBL2333188 1 -
CHEMBL2333186 1 -
CHEMBL2333185 1 -
CHEMBL2333184 1 -
CHEMBL2333183 1 -
CHEMBL2333189 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333187 IC50 = 21.0 nM 7.68
CHEMBL2333194 IC50 = 2110.0 nM 5.68
CHEMBL2333200 IC50 = 3810.0 nM 5.42
CHEMBL2333198 IC50 > 6250.0 nM -
CHEMBL2333197 IC50 > 6250.0 nM -
CHEMBL2333196 IC50 > 6250.0 nM -
CHEMBL2333195 IC50 > 6250.0 nM -
CHEMBL2333193 IC50 > 6250.0 nM -
CHEMBL2333192 IC50 > 6250.0 nM -
CHEMBL2333191 IC50 > 6250.0 nM -
CHEMBL2333190 IC50 > 6250.0 nM -
CHEMBL2333199 IC50 > 6250.0 nM -
CHEMBL2333188 IC50 > 6250.0 nM -
CHEMBL2333186 IC50 > 6250.0 nM -
CHEMBL2333185 IC50 > 6250.0 nM -
CHEMBL2333184 IC50 > 6250.0 nM -
CHEMBL2333183 IC50 > 6250.0 nM -
CHEMBL2333189 IC50 > 6250.0 nM -