Assay Detail
Functional
CHEMBL2344671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 60 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucose-dependent insulinotropic receptor (CHEMBL5652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.92 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336753 | — | — | 1 | 6.00 |
| CHEMBL2336759 | — | — | 1 | 6.00 |
| CHEMBL2336769 | — | — | 1 | 6.00 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | — | 1 | 5.66 |
| CHEMBL2336757 | — | — | 1 | - |
| CHEMBL2336756 | — | — | 1 | - |
| CHEMBL2336755 | — | — | 1 | - |
| CHEMBL2336754 | — | — | 1 | - |
| CHEMBL2336771 | — | — | 1 | - |
| CHEMBL2336770 | — | — | 1 | - |
| CHEMBL2336768 | — | — | 1 | - |
| CHEMBL2336767 | — | — | 1 | - |
| CHEMBL2336758 | — | — | 1 | - |
| CHEMBL2336765 | — | — | 1 | - |
| CHEMBL2336764 | — | — | 1 | - |
| CHEMBL2336762 | — | — | 1 | - |
| CHEMBL2336761 | — | — | 1 | - |
| CHEMBL2336760 | — | — | 1 | - |
| CHEMBL2336766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336753 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2336759 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2336769 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2336757 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336756 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336755 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336754 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336771 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336770 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336768 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336767 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336758 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336765 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336764 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336762 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336761 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336760 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2336766 | — | EC50 | > | 10000.0 | nM | - |