Assay Detail
Functional
CHEMBL2344724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of CGRP-induced dilation on human intracranial arteries
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Artery |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.61 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454791 | — | — | 1 | 10.30 |
| CHEMBL454751 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454791 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL454751 | — | EC50 | = | 1.2 | nM | 8.92 |