Assay Detail
Functional
CHEMBL2344725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CCRP-induced cAMP production
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 16 | - | - |
| EC50 | 1 | 10.77 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454791 | — | — | 2 | 10.77 |
| CHEMBL2336411 | — | — | 1 | - |
| CHEMBL2336412 | — | — | 1 | - |
| CHEMBL2336413 | — | — | 1 | - |
| CHEMBL2336414 | — | — | 1 | - |
| CHEMBL2336415 | — | — | 1 | - |
| CHEMBL2336416 | — | — | 1 | - |
| CHEMBL2336417 | — | — | 1 | - |
| CHEMBL2336418 | — | — | 1 | - |
| CHEMBL2336419 | — | — | 1 | - |
| CHEMBL2336420 | — | — | 1 | - |
| CHEMBL2336421 | — | — | 1 | - |
| CHEMBL2336422 | — | — | 1 | - |
| CHEMBL2336423 | — | — | 1 | - |
| CHEMBL2336424 | — | — | 1 | - |
| CHEMBL454751 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454791 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL2336420 | — | Inhibition | - | % | - | |
| CHEMBL2336411 | — | Inhibition | - | % | - | |
| CHEMBL2336412 | — | Inhibition | - | % | - | |
| CHEMBL2336413 | — | Inhibition | - | % | - | |
| CHEMBL2336414 | — | Inhibition | - | % | - | |
| CHEMBL2336415 | — | Inhibition | - | % | - | |
| CHEMBL2336416 | — | Inhibition | - | % | - | |
| CHEMBL2336417 | — | Inhibition | - | % | - | |
| CHEMBL2336419 | — | Inhibition | - | % | - | |
| CHEMBL2336421 | — | Inhibition | - | % | - | |
| CHEMBL2336422 | — | Inhibition | - | % | - | |
| CHEMBL2336423 | — | Inhibition | - | % | - | |
| CHEMBL454791 | — | Inhibition | - | % | - | |
| CHEMBL2336424 | — | Inhibition | - | % | - | |
| CHEMBL454751 | — | Inhibition | - | % | - | |
| CHEMBL2336418 | — | Inhibition | - | % | - |