Assay Detail
Binding
CHEMBL2344728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CGRP receptor (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 10.00 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336422 | — | — | 1 | 10.96 |
| CHEMBL2336424 | — | — | 1 | 10.92 |
| CHEMBL450668 | — | — | 1 | 10.89 |
| CHEMBL2336411 | — | — | 1 | 10.82 |
| CHEMBL2336416 | — | — | 1 | 10.64 |
| CHEMBL2336418 | — | — | 1 | 10.49 |
| CHEMBL2336417 | — | — | 1 | 10.41 |
| CHEMBL2336419 | — | — | 1 | 10.32 |
| CHEMBL2336415 | — | — | 1 | 10.26 |
| CHEMBL2336412 | — | — | 1 | 9.85 |
| CHEMBL2336420 | — | — | 1 | 9.66 |
| CHEMBL454751 | — | — | 1 | 9.64 |
| CHEMBL2336413 | — | — | 1 | 9.55 |
| CHEMBL2336414 | — | — | 1 | 7.96 |
| CHEMBL2336423 | — | — | 1 | 7.57 |
| CHEMBL2336421 | — | — | 1 | - |
| CHEMBL454791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336422 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL2336424 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL450668 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL2336411 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL2336416 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL2336418 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL2336417 | — | Ki | = | 0.039 | nM | 10.41 |
| CHEMBL2336419 | — | Ki | = | 0.048 | nM | 10.32 |
| CHEMBL2336415 | — | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL2336412 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL2336420 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL454751 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2336413 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL2336414 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2336423 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2336421 | — | Ki | = | 0.005 | nM | - |
| CHEMBL454791 | — | Ki | = | 0.0073 | nM | - |