Assay Detail
Binding
CHEMBL2344809
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Inhibition of Helicobacter pylori alpha-carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
An α-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.69 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.68 |
| CHEMBL961 | DITIOCARB | 2.0 | 1 | 5.30 |
| CHEMBL68253 | SULFAMATE | — | 1 | 4.10 |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
| CHEMBL1207991 | CARBONOTRITHIOIC ACID | — | 1 | - |
| CHEMBL2079226 | ISOSELENOCYANATE | — | 1 | - |
| CHEMBL1161685 | ISOTHIOCYANATE | — | 1 | - |
| CHEMBL1200739 | HYDROGEN SULFIDE | — | 1 | - |
| CHEMBL1161699 | SULFUROUS ACID | — | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 1 | - |
| CHEMBL1233550 | IODIDE | -1.0 | 1 | - |
| CHEMBL1231461 | BROMIDE | — | 1 | - |
| CHEMBL1231821 | HYDROCHLORIC ACID | -1.0 | 1 | - |
| CHEMBL1362 | FLUORIDE ION | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL961 | DITIOCARB | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL68253 | SULFAMATE | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 820000.0 | nM | - |
| CHEMBL1207991 | CARBONOTRITHIOIC ACID | Ki | = | 380000.0 | nM | - |
| CHEMBL2079226 | ISOSELENOCYANATE | Ki | = | 730000.0 | nM | - |
| CHEMBL1161685 | ISOTHIOCYANATE | Ki | = | 4100000.0 | nM | - |
| CHEMBL1200739 | HYDROGEN SULFIDE | Ki | = | 690000.0 | nM | - |
| CHEMBL1161699 | SULFUROUS ACID | Ki | = | 990000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 750000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 6050000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 2410000.0 | nM | - |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 2700000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | = | 4080000.0 | nM | - |