Assay Detail
Binding
CHEMBL2344829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2331570 | — | — | 1 | 7.96 |
| CHEMBL2332840 | — | — | 1 | 7.92 |
| CHEMBL2332849 | — | — | 1 | 7.42 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2331570 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2332840 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2332849 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 90.0 | nM | 7.05 |