Assay Detail
Binding
CHEMBL2345138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylcholine iodide as substrate after 10 mins by Ellman method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.95 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337271 | DONEPEZIL HYDROCHLORIDE MONOHYDRATE | — | 1 | 7.70 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.30 |
| CHEMBL396226 | — | — | 1 | 7.22 |
| CHEMBL2337278 | — | — | 1 | 7.05 |
| CHEMBL2337272 | — | — | 1 | 6.80 |
| CHEMBL2337264 | — | — | 1 | 6.77 |
| CHEMBL2337265 | — | — | 1 | 6.72 |
| CHEMBL2337269 | — | — | 1 | 6.17 |
| CHEMBL2337273 | — | — | 1 | 5.97 |
| CHEMBL2337263 | — | — | 1 | 5.81 |
| CHEMBL2337274 | — | — | 1 | 5.81 |
| CHEMBL2337267 | — | — | 1 | 5.76 |
| CHEMBL2337280 | — | — | 1 | 5.73 |
| CHEMBL243254 | — | — | 1 | 5.72 |
| CHEMBL2337268 | — | — | 1 | 5.67 |
| CHEMBL2337261 | — | — | 1 | 5.66 |
| CHEMBL2337266 | — | — | 1 | 4.72 |
| CHEMBL2337262 | — | — | 1 | 4.71 |
| CHEMBL2337270 | — | — | 1 | 4.68 |
| CHEMBL2337279 | — | — | 1 | 4.57 |
| CHEMBL2337277 | — | — | 1 | 4.34 |
| CHEMBL2337275 | — | — | 1 | - |
| CHEMBL2337276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337271 | DONEPEZIL HYDROCHLORIDE MONOHYDRATE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL396226 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2337278 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2337272 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2337264 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2337265 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2337269 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2337273 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2337263 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL2337274 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL2337267 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2337280 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL243254 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2337268 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2337261 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL2337266 | — | IC50 | = | 19210.0 | nM | 4.72 |
| CHEMBL2337262 | — | IC50 | = | 19340.0 | nM | 4.71 |
| CHEMBL2337270 | — | IC50 | = | 20860.0 | nM | 4.68 |
| CHEMBL2337279 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL2337277 | — | IC50 | = | 45260.0 | nM | 4.34 |
| CHEMBL2337275 | — | IC50 | = | 128420.0 | nM | - |
| CHEMBL2337276 | — | IC50 | = | 112010.0 | nM | - |