Assay Detail
Functional
CHEMBL2345245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.31 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | 2.0 | 1 | 8.86 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.77 |
| CHEMBL2335725 | — | — | 1 | 7.13 |
| CHEMBL2335727 | — | — | 1 | 7.06 |
| CHEMBL2335726 | — | — | 1 | 7.02 |
| CHEMBL2336170 | — | — | 1 | 6.90 |
| CHEMBL2336169 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2335725 | — | IC50 | = | 73.25 | nM | 7.13 |
| CHEMBL2335727 | — | IC50 | = | 87.55 | nM | 7.06 |
| CHEMBL2335726 | — | IC50 | = | 94.73 | nM | 7.02 |
| CHEMBL2336170 | — | IC50 | = | 125.35 | nM | 6.90 |
| CHEMBL2336169 | — | IC50 | = | 347.36 | nM | 6.46 |