Assay Detail
Binding
CHEMBL2345503
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Inhibition of HIV1 reverse transcriptase after 1 hr by colorimetric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.00 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337416 | — | — | 1 | 8.52 |
| CHEMBL2337437 | — | — | 1 | 8.00 |
| CHEMBL2337432 | — | — | 1 | 7.48 |
| CHEMBL2337433 | — | — | 1 | 7.23 |
| CHEMBL436546 | — | — | 1 | 7.06 |
| CHEMBL2337430 | — | — | 1 | 6.89 |
| CHEMBL2337436 | — | — | 1 | 6.82 |
| CHEMBL2337431 | — | — | 1 | 6.80 |
| CHEMBL2337429 | — | — | 1 | 6.39 |
| CHEMBL2337428 | — | — | 1 | 6.23 |
| CHEMBL2337435 | — | — | 1 | 6.19 |
| CHEMBL2337427 | — | — | 1 | 5.92 |
| CHEMBL2337438 | — | — | 1 | 5.88 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.35 |
| CHEMBL2331616 | — | — | 1 | 5.28 |
| CHEMBL2337421 | — | — | 1 | 4.70 |
| CHEMBL2337422 | — | — | 1 | 4.48 |
| CHEMBL2337423 | — | — | 1 | 4.43 |
| CHEMBL2337426 | — | — | 1 | 4.23 |
| CHEMBL2337424 | — | — | 1 | 4.13 |
| CHEMBL2337418 | — | — | 1 | 4.09 |
| CHEMBL2337425 | — | — | 1 | - |
| CHEMBL2337434 | — | — | 1 | - |
| CHEMBL2337420 | — | — | 1 | - |
| CHEMBL2337419 | — | — | 1 | - |
| CHEMBL2337417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337416 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2337437 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2337432 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2337433 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL436546 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2337430 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2337436 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2337431 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2337429 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2337428 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2337435 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2337427 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL2337438 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL2331616 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL2337421 | — | IC50 | = | 19810.0 | nM | 4.70 |
| CHEMBL2337422 | — | IC50 | = | 32880.0 | nM | 4.48 |
| CHEMBL2337423 | — | IC50 | = | 37070.0 | nM | 4.43 |
| CHEMBL2337426 | — | IC50 | = | 59300.0 | nM | 4.23 |
| CHEMBL2337424 | — | IC50 | = | 73540.0 | nM | 4.13 |
| CHEMBL2337418 | — | IC50 | = | 80990.0 | nM | 4.09 |
| CHEMBL2337425 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2337434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2337420 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2337419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2337417 | — | IC50 | > | 100000.0 | nM | - |