Assay Detail
Binding
CHEMBL2345534
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Binding affinity to Mcl-1 (unknown origin) by fluorescence polarization assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.51 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226578 | — | — | 2 | 7.75 |
| CHEMBL258819 | — | — | 2 | 7.43 |
| CHEMBL259033 | — | — | 2 | 6.47 |
| CHEMBL270268 | — | — | 2 | 6.42 |
| CHEMBL389660 | — | — | 2 | 6.40 |
| CHEMBL226678 | — | — | 2 | 5.77 |
| CHEMBL269836 | — | — | 2 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226578 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL226578 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL258819 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL258819 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL259033 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL259033 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL270268 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL270268 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL389660 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL389660 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL226678 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL226678 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL269836 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL269836 | — | Ki | = | 4600.0 | nM | 5.34 |