Assay Detail
Binding
CHEMBL2345645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of goat brain tubulin polymerization incubated for 20 mins prior to GTP addition measured for 30 mins by 90 degree light scattering-based fluorescence spectrophotometric method
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.35 | 5.92 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 5.92 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.82 |
| CHEMBL2332012 | — | — | 2 | 5.22 |
| CHEMBL379989 | RHIZOXIN | — | 1 | 5.17 |
| CHEMBL35769 | DOLASTATIN 15 | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2332012 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL379989 | RHIZOXIN | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL35769 | DOLASTATIN 15 | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2332012 | — | Inhibition | - | % | - |