Assay Detail
ADMET
CHEMBL2345685
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Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.50 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.41 |
| CHEMBL1651049 | — | — | 1 | 4.99 |
| CHEMBL2332990 | — | — | 1 | 4.94 |
| CHEMBL1651058 | — | — | 1 | 4.93 |
| CHEMBL1651052 | LAKSHMININE | — | 1 | 4.75 |
| CHEMBL1917526 | — | — | 1 | 4.55 |
| CHEMBL2312006 | — | — | 1 | 4.54 |
| CHEMBL2332984 | — | — | 1 | 4.44 |
| CHEMBL1651053 | — | — | 1 | 4.43 |
| CHEMBL461133 | — | — | 1 | 4.38 |
| CHEMBL2332982 | — | — | 1 | 4.38 |
| CHEMBL1917527 | — | — | 1 | 4.37 |
| CHEMBL2332983 | — | — | 1 | 4.30 |
| CHEMBL1917528 | — | — | 1 | 4.19 |
| CHEMBL1651056 | — | — | 1 | 4.18 |
| CHEMBL1651057 | — | — | 1 | 4.10 |
| CHEMBL1651054 | — | — | 1 | 4.07 |
| CHEMBL2332988 | — | — | 1 | 4.02 |
| CHEMBL2332989 | — | — | 1 | - |
| CHEMBL1651055 | — | — | 1 | - |
| CHEMBL2312004 | — | — | 1 | - |
| CHEMBL2312005 | — | — | 1 | - |
| CHEMBL2312003 | — | — | 1 | - |
| CHEMBL55659 | ANTHRAQUINONE | — | 1 | - |
| CHEMBL2332985 | 2-METHOXYANTHRAQUINONE | — | 1 | - |
| CHEMBL451977 | — | — | 1 | - |
| CHEMBL52884 | — | — | 1 | - |
| CHEMBL2332986 | — | — | 1 | - |
| CHEMBL2332987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1651049 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2332990 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1651058 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1651052 | LAKSHMININE | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1917526 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2312006 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL2332984 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL1651053 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL461133 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL2332982 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL1917527 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL2332983 | — | IC50 | = | 50500.0 | nM | 4.30 |
| CHEMBL1917528 | — | IC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL1651056 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL1651057 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1651054 | — | IC50 | = | 85200.0 | nM | 4.07 |
| CHEMBL2332988 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL2332989 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1651055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2312004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2312005 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2312003 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL55659 | ANTHRAQUINONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2332985 | 2-METHOXYANTHRAQUINONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL451977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52884 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2332986 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2332987 | — | IC50 | > | 100000.0 | nM | - |