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Assay Detail

CHEMBL2345690

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Functional
Antimalarial activity against Plasmodium falciparum K1 assessed as parasite growth inhibition after 72 hrs by MSF assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents.
Chauhan K, Sharma M, Saxena J, Singh SV, Trivedi P, Srivastava K, Puri SK, Saxena JK, Chaturvedi V, Chauhan PM.
Eur J Med Chem (2013) 62 : 693 -704
PubMed 23454512 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.04 7.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2332993 1 7.88
CHEMBL2333013 1 7.38
CHEMBL2333003 1 7.35
CHEMBL2332991 1 7.34
CHEMBL2332992 1 7.30
CHEMBL2333010 1 7.26
CHEMBL2333004 1 7.24
CHEMBL2333001 1 7.23
CHEMBL2333014 1 7.23
CHEMBL2332995 1 7.18
CHEMBL2333011 1 7.15
CHEMBL2333002 1 7.10
CHEMBL2332996 1 7.08
CHEMBL2333009 1 7.05
CHEMBL2332994 1 7.03
CHEMBL2332998 1 7.02
CHEMBL2332997 1 6.98
CHEMBL2333006 1 6.84
CHEMBL2333008 1 6.82
CHEMBL2333005 1 6.82
CHEMBL76 CHLOROQUINE 4.0 1 6.59
CHEMBL2333012 1 6.55
CHEMBL2333007 1 6.51
CHEMBL2333000 1 6.08
CHEMBL2332999 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2332993 IC50 = 13.2 nM 7.88
CHEMBL2333013 IC50 = 42.2 nM 7.38
CHEMBL2333003 IC50 = 45.1 nM 7.35
CHEMBL2332991 IC50 = 45.5 nM 7.34
CHEMBL2332992 IC50 = 50.4 nM 7.30
CHEMBL2333010 IC50 = 54.6 nM 7.26
CHEMBL2333004 IC50 = 58.2 nM 7.24
CHEMBL2333001 IC50 = 59.3 nM 7.23
CHEMBL2333014 IC50 = 59.3 nM 7.23
CHEMBL2332995 IC50 = 66.2 nM 7.18
CHEMBL2333011 IC50 = 70.1 nM 7.15
CHEMBL2333002 IC50 = 80.1 nM 7.10
CHEMBL2332996 IC50 = 83.8 nM 7.08
CHEMBL2333009 IC50 = 88.8 nM 7.05
CHEMBL2332994 IC50 = 94.2 nM 7.03
CHEMBL2332998 IC50 = 95.7 nM 7.02
CHEMBL2332997 IC50 = 104.1 nM 6.98
CHEMBL2333006 IC50 = 143.9 nM 6.84
CHEMBL2333008 IC50 = 151.4 nM 6.82
CHEMBL2333005 IC50 = 153.0 nM 6.82
CHEMBL76 CHLOROQUINE IC50 = 254.05 nM 6.59
CHEMBL2333012 IC50 = 284.2 nM 6.55
CHEMBL2333007 IC50 = 308.4 nM 6.51
CHEMBL2333000 IC50 = 840.3 nM 6.08
CHEMBL2332999 IC50 > 1104.0 nM -