Assay Detail
Binding
CHEMBL2346192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.18 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333927 | — | — | 1 | 7.85 |
| CHEMBL2333925 | — | — | 1 | 7.65 |
| CHEMBL2333926 | — | — | 1 | 7.63 |
| CHEMBL2333933 | — | — | 1 | 7.44 |
| CHEMBL2333934 | — | — | 1 | 7.28 |
| CHEMBL2333930 | — | — | 1 | 7.26 |
| CHEMBL2333935 | — | — | 1 | 7.11 |
| CHEMBL2333929 | — | — | 1 | 7.10 |
| CHEMBL2333928 | — | — | 1 | 7.09 |
| CHEMBL2333932 | — | — | 1 | 7.08 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.96 |
| CHEMBL2333936 | — | — | 1 | 6.86 |
| CHEMBL2333937 | — | — | 1 | 6.83 |
| CHEMBL2333931 | — | — | 1 | 6.34 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333927 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL2333925 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL2333926 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL2333933 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL2333934 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2333930 | — | IC50 | = | 55.4 | nM | 7.26 |
| CHEMBL2333935 | — | IC50 | = | 77.6 | nM | 7.11 |
| CHEMBL2333929 | — | IC50 | = | 79.3 | nM | 7.10 |
| CHEMBL2333928 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2333932 | — | IC50 | = | 83.1 | nM | 7.08 |
| CHEMBL95 | TACRINE | IC50 | = | 110.2 | nM | 6.96 |
| CHEMBL2333936 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL2333937 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL2333931 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL673 | PARGYLINE | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |