Assay Detail
Functional
CHEMBL2349694
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Antiproliferative activity against human MCF7 cells transfected with human sigma1 receptor after 48 hrs by MTT assay
20
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 4.11 | 4.51 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 4.51 |
| CHEMBL73824 | — | — | 1 | 4.16 |
| CHEMBL1195399 | — | — | 2 | 4.00 |
| CHEMBL1189823 | — | — | 2 | 4.00 |
| CHEMBL2349068 | — | — | 2 | 4.00 |
| CHEMBL2349072 | — | — | 2 | 4.00 |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | — | 1 | - |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | - |
| CHEMBL1190213 | — | — | 1 | - |
| CHEMBL1188789 | — | — | 1 | - |
| CHEMBL2349066 | — | — | 1 | - |
| CHEMBL2349067 | — | — | 1 | - |
| CHEMBL2349069 | — | — | 1 | - |
| CHEMBL2349070 | — | — | 1 | - |
| CHEMBL2349071 | — | — | 1 | - |
| CHEMBL2349073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | EC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL73824 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2349072 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1195399 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2349068 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1189823 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1189823 | — | Activity | = | 14.0 | % | - |
| CHEMBL2349068 | — | Activity | = | 12.0 | % | - |
| CHEMBL2349072 | — | Activity | = | 14.0 | % | - |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL60542 | (+)-PENTAZOCINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL1190213 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1188789 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2349066 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2349067 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2349069 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2349070 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2349071 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1195399 | — | Activity | = | 18.0 | % | - |
| CHEMBL2349073 | — | EC50 | > | 100000.0 | nM | - |