Assay Detail
Binding
CHEMBL2349697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma 2 receptor in Wistar Hannover rat liver membrane by competition binding assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.19 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349072 | — | — | 1 | 7.96 |
| CHEMBL2349068 | — | — | 1 | 7.86 |
| CHEMBL1195399 | — | — | 1 | 7.54 |
| CHEMBL1189823 | — | — | 1 | 7.53 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.52 |
| CHEMBL2349069 | — | — | 1 | 7.34 |
| CHEMBL2349070 | — | — | 1 | 7.16 |
| CHEMBL2349066 | — | — | 1 | 7.04 |
| CHEMBL2349073 | — | — | 1 | 7.04 |
| CHEMBL1190213 | — | — | 1 | 7.03 |
| CHEMBL1188789 | — | — | 1 | 6.94 |
| CHEMBL2349067 | — | — | 1 | 6.30 |
| CHEMBL2349071 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349072 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL2349068 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL1195399 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL1189823 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL2349069 | — | Ki | = | 45.4 | nM | 7.34 |
| CHEMBL2349070 | — | Ki | = | 69.8 | nM | 7.16 |
| CHEMBL2349066 | — | Ki | = | 90.7 | nM | 7.04 |
| CHEMBL2349073 | — | Ki | = | 90.9 | nM | 7.04 |
| CHEMBL1190213 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL1188789 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL2349067 | — | Ki | = | 495.0 | nM | 6.30 |
| CHEMBL2349071 | — | Ki | = | 641.0 | nM | 6.19 |