Assay Detail
Binding
CHEMBL2349751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.15 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349194 | — | — | 1 | 8.03 |
| CHEMBL2347577 | — | — | 1 | 7.93 |
| CHEMBL2347575 | — | — | 1 | 7.88 |
| CHEMBL2347574 | — | — | 1 | 7.72 |
| CHEMBL2347578 | — | — | 1 | 7.72 |
| CHEMBL2347579 | — | — | 1 | 7.70 |
| CHEMBL2347580 | — | — | 1 | 7.70 |
| CHEMBL2347576 | — | — | 1 | 7.61 |
| CHEMBL2349193 | — | — | 1 | 7.60 |
| CHEMBL2349188 | — | — | 1 | 7.51 |
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 7.30 |
| CHEMBL2349190 | — | — | 1 | 7.23 |
| CHEMBL2349189 | — | — | 1 | 7.22 |
| CHEMBL2349192 | — | — | 1 | 7.21 |
| CHEMBL2347582 | — | — | 1 | 7.16 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.75 |
| CHEMBL2347584 | — | — | 1 | 6.66 |
| CHEMBL2347583 | — | — | 1 | 6.58 |
| CHEMBL2347585 | — | — | 1 | 6.47 |
| CHEMBL2349191 | — | — | 1 | 6.20 |
| CHEMBL2347581 | — | — | 1 | 6.10 |
| CHEMBL76921 | — | — | 1 | 6.05 |
| CHEMBL2347586 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349194 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2347577 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL2347575 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL2347574 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2347578 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2347579 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2347580 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2347576 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL2349193 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2349188 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1094304 | OLOMOUCINE II | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2349190 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2349189 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2349192 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2347582 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2347584 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2347583 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2347585 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2349191 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2347581 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL76921 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2347586 | — | IC50 | = | 890.0 | nM | 6.05 |