Assay Detail
Functional
CHEMBL2350002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin-induced rabbit platelet aggregation compound pre-incubated in rabbit liver microsomal suspension
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Liver |
| Cell Type | Platelet |
| Subcellular | Microsome |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.33 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347120 | — | — | 1 | 6.69 |
| CHEMBL2347117 | — | — | 1 | 6.54 |
| CHEMBL539697 | DABIGATRAN ETEXILATE | 4.0 | 1 | 6.47 |
| CHEMBL2347118 | — | — | 1 | 6.34 |
| CHEMBL2347116 | — | — | 1 | 6.22 |
| CHEMBL2347119 | — | — | 1 | 6.16 |
| CHEMBL2347121 | — | — | 1 | 6.11 |
| CHEMBL2347122 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347120 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL2347117 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL539697 | DABIGATRAN ETEXILATE | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL2347118 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL2347116 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL2347119 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL2347121 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL2347122 | — | IC50 | = | 841.0 | nM | 6.08 |