Assay Detail
Binding
CHEMBL2350561
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Binding affinity to human NRAS G-quadruplex FAM-GGGAGGGGCGGGUCUGGG-TAMRA RNA assessed as quenching of fluorescence emission by FRET titration assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Guanidino anthrathiophenediones as G-quadruplex binders: uptake, intracellular localization, and anti-Harvey-Ras gene activity in bladder cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.91 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349420 | — | — | 1 | 7.22 |
| CHEMBL2349418 | — | — | 1 | 7.05 |
| CHEMBL2349419 | — | — | 1 | 6.96 |
| CHEMBL2349417 | — | — | 1 | 6.92 |
| CHEMBL472033 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349420 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL2349418 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL2349419 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL2349417 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL472033 | — | Kd | = | 380.0 | nM | 6.42 |