Assay Detail
Binding
CHEMBL2350587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to mouse KRAS G-quadruplex FAM-GCGGGAGGGAGGGAAGGAGGGAGGGAGGGAG-TAMRA DNA assessed as quenching of fluorescence emission by FRET titration assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Guanidino anthrathiophenediones as G-quadruplex binders: uptake, intracellular localization, and anti-Harvey-Ras gene activity in bladder cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.65 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349419 | — | — | 1 | 6.75 |
| CHEMBL2349417 | — | — | 1 | 6.68 |
| CHEMBL2349418 | — | — | 1 | 6.64 |
| CHEMBL472033 | — | — | 1 | 6.60 |
| CHEMBL2349420 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349419 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL2349417 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL2349418 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL472033 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL2349420 | — | Kd | = | 270.0 | nM | 6.57 |