Assay Detail
Functional
CHEMBL2350995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.97 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 5.71 |
| CHEMBL1778710 | — | — | 1 | 5.07 |
| CHEMBL2347075 | — | — | 1 | 5.01 |
| CHEMBL2347053 | — | — | 1 | 4.83 |
| CHEMBL2347074 | — | — | 1 | 4.83 |
| CHEMBL2347085 | — | — | 1 | 4.81 |
| CHEMBL2347073 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL1778710 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL2347075 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL2347053 | — | IC50 | = | 14840.0 | nM | 4.83 |
| CHEMBL2347074 | — | IC50 | = | 14670.0 | nM | 4.83 |
| CHEMBL2347085 | — | IC50 | = | 15540.0 | nM | 4.81 |
| CHEMBL2347073 | — | IC50 | = | 30070.0 | nM | 4.52 |