Assay Detail
ADMET
CHEMBL2351482
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Cytotoxicity against NQO1-deficient human wild type MDA-MB-468 cells incubated for 2 hrs measured after 3 to 5 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new quinolinequinone derivatives and preliminary exploration of their cytotoxic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.59 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347022 | — | — | 1 | 6.85 |
| CHEMBL2347015 | — | — | 1 | 6.28 |
| CHEMBL2347014 | — | — | 1 | 6.10 |
| CHEMBL2347012 | — | — | 1 | 5.77 |
| CHEMBL2347013 | — | — | 1 | 5.48 |
| CHEMBL2347023 | — | — | 1 | 5.35 |
| CHEMBL2347021 | — | — | 1 | 5.32 |
| CHEMBL2347019 | — | — | 1 | 5.28 |
| CHEMBL2347020 | — | — | 1 | 5.25 |
| CHEMBL2347017 | — | — | 1 | 5.13 |
| CHEMBL57818 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347022 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2347015 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2347014 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2347012 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2347013 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2347023 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2347021 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2347019 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2347020 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2347017 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL57818 | — | IC50 | = | 19000.0 | nM | 4.72 |