Assay Detail
Functional
CHEMBL2351578
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.90 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1374751 | CIMATEROL | 2.0 | 1 | 5.00 |
| CHEMBL2348201 | — | — | 1 | 5.00 |
| CHEMBL2348211 | — | — | 1 | 5.00 |
| CHEMBL2348217 | — | — | 1 | 5.00 |
| CHEMBL2348218 | — | — | 1 | 5.00 |
| CHEMBL2348219 | — | — | 1 | 5.00 |
| CHEMBL2348220 | — | — | 1 | 5.00 |
| CHEMBL207802 | LK-204545 | — | 1 | 5.00 |
| CHEMBL3392321 | — | — | 1 | 5.00 |
| CHEMBL75753 | XAMOTEROL | 2.0 | 1 | 4.00 |
| CHEMBL280822 | CGP-20712A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1374751 | CIMATEROL | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348201 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348211 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348217 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348218 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348219 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2348220 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL207802 | LK-204545 | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3392321 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75753 | XAMOTEROL | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL280822 | CGP-20712A | EC50 | - | — | - |