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Assay Detail

CHEMBL2351674

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Dengue virus infected in BHK cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Dengue virus
Cell Type BHK
Confidence 1 — Organism
Curated By Autocuration

Target

Dengue virus (CHEMBL613757)
Type ORGANISM
Organism Dengue virus

Publication

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.
Du Y, Ye H, Gill T, Wang L, Guo F, Cuconati A, Guo JT, Block TM, Chang J, Xu X.
Bioorg Med Chem Lett (2013) 23 : 2172 -2176
PubMed 23453839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 5.90 6.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2348371 1 6.90
CHEMBL2348382 1 6.55
CHEMBL2348484 1 6.52
CHEMBL2348383 1 6.50
CHEMBL2348372 1 6.10
CHEMBL2348373 1 6.10
CHEMBL2348370 1 5.86
CHEMBL2348380 1 5.82
CHEMBL2348375 1 5.72
CHEMBL2348374 1 5.70
CHEMBL2348379 1 5.66
CHEMBL2348377 1 5.27
CHEMBL2348376 1 5.06
CHEMBL2348381 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2348371 EC50 = 125.0 nM 6.90
CHEMBL2348382 EC50 = 280.0 nM 6.55
CHEMBL2348484 EC50 = 300.0 nM 6.52
CHEMBL2348383 EC50 = 320.0 nM 6.50
CHEMBL2348372 EC50 = 800.0 nM 6.10
CHEMBL2348373 EC50 = 800.0 nM 6.10
CHEMBL2348370 EC50 = 1380.0 nM 5.86
CHEMBL2348380 EC50 = 1500.0 nM 5.82
CHEMBL2348375 EC50 = 1900.0 nM 5.72
CHEMBL2348374 EC50 = 2000.0 nM 5.70
CHEMBL2348379 EC50 = 2200.0 nM 5.66
CHEMBL2348377 EC50 = 5400.0 nM 5.27
CHEMBL2348376 EC50 = 8800.0 nM 5.06
CHEMBL2348381 EC50 = 14000.0 nM 4.85