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Assay Detail

CHEMBL2351677

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against BVDV infected in MDBK cells assessed as reduction of viral yield
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Bovine viral diarrhea virus 1
Cell Type MDBK
Confidence 1 — Organism
Curated By Autocuration

Target

Bovine viral diarrhea virus 1 (CHEMBL612571)
Type ORGANISM
Organism Bovine viral diarrhea virus 1

Publication

N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.
Du Y, Ye H, Gill T, Wang L, Guo F, Cuconati A, Guo JT, Block TM, Chang J, Xu X.
Bioorg Med Chem Lett (2013) 23 : 2172 -2176
PubMed 23453839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 6.14 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2348380 1 6.75
CHEMBL2348382 1 6.70
CHEMBL2348370 1 6.68
CHEMBL2348383 1 6.66
CHEMBL2348372 1 6.62
CHEMBL2348379 1 6.60
CHEMBL2348381 1 6.55
CHEMBL2348371 1 6.51
CHEMBL2348373 1 6.40
CHEMBL2348484 1 6.40
CHEMBL2348377 1 6.40
CHEMBL2348375 1 6.10
CHEMBL2348374 1 6.07
CHEMBL2348483 1 5.60
CHEMBL2348485 1 5.48
CHEMBL2348376 1 5.43
CHEMBL2348384 1 5.30
CHEMBL2348378 1 5.22
CHEMBL2348385 1 5.20
CHEMBL2348386 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2348380 EC50 = 180.0 nM 6.75
CHEMBL2348382 EC50 = 200.0 nM 6.70
CHEMBL2348370 EC50 = 210.0 nM 6.68
CHEMBL2348383 EC50 = 220.0 nM 6.66
CHEMBL2348372 EC50 = 240.0 nM 6.62
CHEMBL2348379 EC50 = 250.0 nM 6.60
CHEMBL2348381 EC50 = 280.0 nM 6.55
CHEMBL2348371 EC50 = 310.0 nM 6.51
CHEMBL2348373 EC50 = 400.0 nM 6.40
CHEMBL2348484 EC50 = 400.0 nM 6.40
CHEMBL2348377 EC50 = 400.0 nM 6.40
CHEMBL2348375 EC50 = 800.0 nM 6.10
CHEMBL2348374 EC50 = 850.0 nM 6.07
CHEMBL2348483 EC50 = 2500.0 nM 5.60
CHEMBL2348485 EC50 = 3300.0 nM 5.48
CHEMBL2348376 EC50 = 3750.0 nM 5.43
CHEMBL2348384 EC50 = 5000.0 nM 5.30
CHEMBL2348378 EC50 = 6000.0 nM 5.22
CHEMBL2348385 EC50 = 6300.0 nM 5.20
CHEMBL2348386 EC50 > 100000.0 nM -