Assay Detail
Binding
CHEMBL2351872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]KA from KA receptor in rat cortical synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.09 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348224 | — | — | 1 | 6.96 |
| CHEMBL282842 | — | — | 1 | 6.51 |
| CHEMBL2348221 | — | — | 1 | 6.21 |
| CHEMBL2348222 | — | — | 1 | 4.68 |
| CHEMBL2348223 | — | — | 1 | - |
| CHEMBL444979 | — | — | 1 | - |
| CHEMBL504772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348224 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL282842 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2348221 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL2348222 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2348223 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL444979 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL504772 | — | Ki | > | 100000.0 | nM | - |