Assay Detail
Functional
CHEMBL2352065
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Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by WST1 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.17 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348864 | — | — | 1 | 6.83 |
| CHEMBL2348865 | — | — | 1 | 6.65 |
| CHEMBL2348862 | — | — | 1 | 5.81 |
| CHEMBL2348863 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348864 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL2348865 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL2348862 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL2348863 | — | IC50 | = | 4180.0 | nM | 5.38 |