Assay Detail
Binding
CHEMBL2352069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mTOR (unknown origin) using GST-p70S6 as substrate after 60 mins by TR-FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348865 | — | — | 1 | 8.70 |
| CHEMBL2348864 | — | — | 1 | 8.10 |
| CHEMBL2348862 | — | — | 1 | 6.97 |
| CHEMBL2348863 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348865 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2348864 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2348862 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2348863 | — | IC50 | = | 176.0 | nM | 6.75 |