Assay Detail
Binding
CHEMBL2352972
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Inhibition of recombinant Toxoplasma gondii DXR catalytic domain (68 to 513) expressed in Escherichia coli BL21 using DXP as substrate after 10 mins by Uv-spectrophotometric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.40 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | — | 1 | 7.32 |
| CHEMBL2323928 | — | — | 1 | 7.26 |
| CHEMBL204106 | — | — | 1 | 7.11 |
| CHEMBL2323929 | — | — | 1 | 7.10 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.05 |
| CHEMBL204107 | — | — | 1 | 6.66 |
| CHEMBL2323931 | — | — | 1 | 6.28 |
| CHEMBL2323930 | — | — | 1 | 6.01 |
| CHEMBL1615246 | — | — | 1 | 5.68 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | — | 1 | 5.39 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL2323928 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL204106 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2323929 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL203125 | FOSMIDOMYCIN | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL204107 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2323931 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL2323930 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL1615246 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | Ki | = | 25600.0 | nM | 4.59 |