Assay Detail
Binding
CHEMBL2353364
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Inhibition of TNFalpha-induced NFkappaB activation in mouse C2C12 cells incubated for 24 hrs prior to TNFalpha induction measured after 24 hrs by luciferase reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C2C12 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.50 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348781 | — | — | 1 | 7.27 |
| CHEMBL2348779 | — | — | 1 | 7.25 |
| CHEMBL2005968 | — | — | 1 | 7.21 |
| CHEMBL2348782 | — | — | 1 | 7.20 |
| CHEMBL2348780 | VAMOROLONE | 4.0 | 1 | 7.18 |
| CHEMBL2348784 | — | — | 1 | 7.05 |
| CHEMBL2348787 | — | — | 1 | 7.03 |
| CHEMBL2348783 | — | — | 1 | 6.89 |
| CHEMBL2106613 | ANECORTAVE ACETATE | 3.0 | 1 | 6.67 |
| CHEMBL2348788 | — | — | 1 | 6.36 |
| CHEMBL2348790 | — | — | 1 | 6.30 |
| CHEMBL2348785 | — | — | 1 | 6.14 |
| CHEMBL2348791 | — | — | 1 | 6.00 |
| CHEMBL2348786 | — | — | 1 | 5.76 |
| CHEMBL2348789 | — | — | 1 | 5.73 |
| CHEMBL2348792 | — | — | 1 | 5.28 |
| CHEMBL2348985 | — | — | 1 | 5.24 |
| CHEMBL2348988 | — | — | 1 | - |
| CHEMBL2348986 | — | — | 1 | - |
| CHEMBL2348987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348781 | — | EC50 | = | 54.1 | nM | 7.27 |
| CHEMBL2348779 | — | EC50 | = | 56.4 | nM | 7.25 |
| CHEMBL2005968 | — | EC50 | = | 62.3 | nM | 7.21 |
| CHEMBL2348782 | — | EC50 | = | 62.9 | nM | 7.20 |
| CHEMBL2348780 | VAMOROLONE | EC50 | = | 65.9 | nM | 7.18 |
| CHEMBL2348784 | — | EC50 | = | 89.5 | nM | 7.05 |
| CHEMBL2348787 | — | EC50 | = | 93.6 | nM | 7.03 |
| CHEMBL2348783 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL2106613 | ANECORTAVE ACETATE | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL2348788 | — | EC50 | = | 435.0 | nM | 6.36 |
| CHEMBL2348790 | — | EC50 | = | 495.0 | nM | 6.30 |
| CHEMBL2348785 | — | EC50 | = | 723.0 | nM | 6.14 |
| CHEMBL2348791 | — | EC50 | = | 988.0 | nM | 6.00 |
| CHEMBL2348786 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL2348789 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2348792 | — | EC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL2348985 | — | EC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL2348988 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2348986 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2348987 | — | EC50 | > | 10000.0 | nM | - |