Assay Detail
Binding
CHEMBL2353871
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Competitive inhibition of C-Terminal histidine-tagged wild type heterodimeric HIV-1 reverse transcriptase p66/p51 assessed as inhibition of dTTP incorporation after 15 mins by PAGE
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348625 | — | — | 1 | 8.52 |
| CHEMBL72335 | — | — | 1 | 7.89 |
| CHEMBL2348624 | — | — | 1 | 6.91 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348625 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL72335 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2348624 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | IC50 | = | 13000.0 | nM | 4.89 |