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Assay Detail

CHEMBL2354097

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from mouse CB2 receptor expressed in mouse spleen membrane by competitive binding assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Spleen
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 2 (CHEMBL5373)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Novel adamantyl cannabinoids as CB1 receptor probes.
Thakur GA, Bajaj S, Paronis C, Peng Y, Bowman AL, Barak LS, Caron MG, Parrish D, Deschamps JR, Makriyannis A.
J Med Chem (2013) 56 : 3904 -3921
PubMed 23621789 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.23 8.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2348469 1 8.09
CHEMBL2348472 1 7.97
CHEMBL2348462 1 7.92
CHEMBL2348460 1 7.70
CHEMBL2348470 1 7.68
CHEMBL2348459 1 7.59
CHEMBL2348473 1 7.49
CHEMBL2348466 1 7.46
CHEMBL2348467 1 7.42
CHEMBL2348461 1 7.41
CHEMBL2348474 1 7.38
CHEMBL434351 1 7.28
CHEMBL2348468 1 7.19
CHEMBL2348464 1 7.06
CHEMBL2348465 1 7.04
CHEMBL2348471 1 6.90
CHEMBL2348458 1 6.60
CHEMBL2348476 1 6.60
CHEMBL2346682 1 6.59
CHEMBL2348463 1 6.46
CHEMBL2348475 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2348469 Ki = 8.1 nM 8.09
CHEMBL2348472 Ki = 10.6 nM 7.97
CHEMBL2348462 Ki = 12.1 nM 7.92
CHEMBL2348460 Ki = 20.1 nM 7.70
CHEMBL2348470 Ki = 21.0 nM 7.68
CHEMBL2348459 Ki = 25.7 nM 7.59
CHEMBL2348473 Ki = 32.3 nM 7.49
CHEMBL2348466 Ki = 34.3 nM 7.46
CHEMBL2348467 Ki = 38.4 nM 7.42
CHEMBL2348461 Ki = 39.4 nM 7.41
CHEMBL2348474 Ki = 42.2 nM 7.38
CHEMBL434351 Ki = 52.0 nM 7.28
CHEMBL2348468 Ki = 65.1 nM 7.19
CHEMBL2348464 Ki = 87.0 nM 7.06
CHEMBL2348465 Ki = 90.3 nM 7.04
CHEMBL2348471 Ki = 126.0 nM 6.90
CHEMBL2348458 Ki = 249.5 nM 6.60
CHEMBL2348476 Ki = 251.0 nM 6.60
CHEMBL2346682 Ki = 255.0 nM 6.59
CHEMBL2348463 Ki = 345.8 nM 6.46
CHEMBL2348475 Ki = 950.0 nM 6.02