Assay Detail
Functional
CHEMBL2363143
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SANGER: Inhibition of human COR-L105 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COR-L105 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.51 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.17 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.02 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.94 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.82 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.72 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.53 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.51 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.26 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.18 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.14 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.88 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.88 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.79 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.73 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.72 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.68 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.65 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.64 |
| CHEMBL585951 | — | — | 1 | 6.63 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.49 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.43 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.42 |
| CHEMBL176544 | — | — | 1 | 6.31 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.18 |
| CHEMBL217354 | — | — | 1 | 6.15 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.00 |
| CHEMBL1190711 | — | — | 1 | 5.94 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.79 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.75 |
| CHEMBL191384 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 6.764 | nM | 8.17 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 9.538 | nM | 8.02 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 11.55 | nM | 7.94 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 15.04 | nM | 7.82 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 19.11 | nM | 7.72 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 29.42 | nM | 7.53 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 30.94 | nM | 7.51 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 54.47 | nM | 7.26 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 65.75 | nM | 7.18 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 71.71 | nM | 7.14 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 130.97 | nM | 6.88 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 132.32 | nM | 6.88 |
| CHEMBL803 | CYTARABINE | IC50 | = | 160.39 | nM | 6.79 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 184.93 | nM | 6.73 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 188.92 | nM | 6.72 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 210.84 | nM | 6.68 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 222.35 | nM | 6.65 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 230.34 | nM | 6.64 |
| CHEMBL585951 | — | IC50 | = | 235.32 | nM | 6.63 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 322.18 | nM | 6.49 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 370.71 | nM | 6.43 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 379.3 | nM | 6.42 |
| CHEMBL176544 | — | IC50 | = | 494.21 | nM | 6.31 |
| CHEMBL939 | GEFITINIB | IC50 | = | 662.53 | nM | 6.18 |
| CHEMBL217354 | — | IC50 | = | 710.65 | nM | 6.15 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1003.94 | nM | 6.00 |
| CHEMBL1190711 | — | IC50 | = | 1137.54 | nM | 5.94 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1613.17 | nM | 5.79 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1797.37 | nM | 5.75 |
| CHEMBL191384 | — | IC50 | = | 1774.71 | nM | 5.75 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2163.73 | nM | 5.67 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 3134.62 | nM | 5.50 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 3633.34 | nM | 5.44 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4018.0 | nM | 5.40 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4130.51 | nM | 5.38 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 4386.76 | nM | 5.36 |
| CHEMBL512504 | — | IC50 | = | 4514.62 | nM | 5.34 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 6379.81 | nM | 5.20 |
| CHEMBL105442 | CI-1040 | IC50 | = | 6652.75 | nM | 5.18 |
| CHEMBL2363137 | — | IC50 | = | 6575.45 | nM | 5.18 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7236.14 | nM | 5.14 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 7365.34 | nM | 5.13 |
| CHEMBL472940 | — | IC50 | = | 7361.58 | nM | 5.13 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 7714.21 | nM | 5.11 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9569.53 | nM | 5.02 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 11323.74 | nM | 4.95 |
| CHEMBL202721 | — | IC50 | = | 12142.15 | nM | 4.92 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 13864.99 | nM | 4.86 |
| CHEMBL3349342 | — | IC50 | = | 14050.71 | nM | 4.85 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 14675.51 | nM | 4.83 |