Assay Detail
Functional
CHEMBL2363237
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SANGER: Inhibition of human GAMG cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GAMG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.68 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.38 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.82 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.75 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.60 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.43 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.42 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.05 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.88 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.86 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.71 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.46 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.24 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL217354 | — | — | 1 | 6.67 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.54 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.43 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.42 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.41 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.41 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.37 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.30 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.25 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.13 |
| CHEMBL573107 | — | — | 1 | 6.13 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.09 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.02 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.00 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.99 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.4156 | nM | 9.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.527 | nM | 8.82 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.785 | nM | 8.75 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.51 | nM | 8.60 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 3.739 | nM | 8.43 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3.823 | nM | 8.42 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.864 | nM | 8.05 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 13.03 | nM | 7.88 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.71 | nM | 7.86 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 19.38 | nM | 7.71 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 19.48 | nM | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 34.35 | nM | 7.46 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 59.96 | nM | 7.22 |
| CHEMBL217354 | — | IC50 | = | 212.38 | nM | 6.67 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 289.35 | nM | 6.54 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 370.85 | nM | 6.43 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL803 | CYTARABINE | IC50 | = | 393.64 | nM | 6.41 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 385.67 | nM | 6.41 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 428.21 | nM | 6.37 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 497.57 | nM | 6.30 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 556.58 | nM | 6.25 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 736.53 | nM | 6.13 |
| CHEMBL573107 | — | IC50 | = | 747.17 | nM | 6.13 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 804.97 | nM | 6.09 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 961.06 | nM | 6.02 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1010.77 | nM | 6.00 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1023.72 | nM | 5.99 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1178.66 | nM | 5.93 |
| CHEMBL585951 | — | IC50 | = | 1335.77 | nM | 5.87 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1709.71 | nM | 5.77 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2238.45 | nM | 5.65 |
| CHEMBL379975 | — | IC50 | = | 2377.11 | nM | 5.62 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2445.61 | nM | 5.61 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2593.94 | nM | 5.59 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2613.55 | nM | 5.58 |
| CHEMBL577784 | BX-795 | IC50 | = | 2826.33 | nM | 5.55 |
| CHEMBL189584 | PD-173074 | IC50 | = | 3465.76 | nM | 5.46 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3913.14 | nM | 5.41 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3901.32 | nM | 5.41 |
| CHEMBL105442 | CI-1040 | IC50 | = | 4023.77 | nM | 5.39 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4429.48 | nM | 5.35 |
| CHEMBL202721 | — | IC50 | = | 5147.57 | nM | 5.29 |
| CHEMBL393929 | — | IC50 | = | 5371.5 | nM | 5.27 |
| CHEMBL2363137 | — | IC50 | = | 5576.17 | nM | 5.25 |
| CHEMBL258844 | — | IC50 | = | 5685.62 | nM | 5.25 |
| CHEMBL3349342 | — | IC50 | = | 5688.02 | nM | 5.25 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 6177.76 | nM | 5.21 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6506.2 | nM | 5.19 |