Assay Detail
Functional
CHEMBL2363250
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SANGER: Inhibition of human H4 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.95 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.21 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.01 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.97 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.71 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.70 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.66 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.23 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.14 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.11 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.91 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.90 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.87 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.87 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.51 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.14 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.86 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.66 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.56 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.55 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.53 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.49 |
| CHEMBL217354 | — | — | 1 | 6.39 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.37 |
| CHEMBL585951 | — | — | 1 | 6.36 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.34 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.22 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 6.18 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.07 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.6154 | nM | 9.21 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.975 | nM | 9.01 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1.073 | nM | 8.97 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.963 | nM | 8.71 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.982 | nM | 8.70 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.175 | nM | 8.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.837 | nM | 8.23 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.851 | nM | 8.11 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 12.44 | nM | 7.91 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 12.67 | nM | 7.90 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.66 | nM | 7.87 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 21.45 | nM | 7.67 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 71.56 | nM | 7.14 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 139.63 | nM | 6.86 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 220.62 | nM | 6.66 |
| CHEMBL803 | CYTARABINE | IC50 | = | 274.45 | nM | 6.56 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 283.93 | nM | 6.55 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 296.54 | nM | 6.53 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 320.74 | nM | 6.49 |
| CHEMBL217354 | — | IC50 | = | 408.12 | nM | 6.39 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 424.51 | nM | 6.37 |
| CHEMBL585951 | — | IC50 | = | 438.69 | nM | 6.36 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 461.61 | nM | 6.34 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 600.94 | nM | 6.22 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 662.8 | nM | 6.18 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 850.85 | nM | 6.07 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 903.56 | nM | 6.04 |
| CHEMBL379975 | — | IC50 | = | 953.44 | nM | 6.02 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1064.22 | nM | 5.97 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 1067.07 | nM | 5.97 |
| CHEMBL577784 | BX-795 | IC50 | = | 1102.01 | nM | 5.96 |
| CHEMBL393929 | — | IC50 | = | 1158.75 | nM | 5.94 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1154.39 | nM | 5.94 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1208.37 | nM | 5.92 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1219.51 | nM | 5.91 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1242.55 | nM | 5.91 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1509.12 | nM | 5.82 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1732.12 | nM | 5.76 |
| CHEMBL202721 | — | IC50 | = | 1815.78 | nM | 5.74 |
| CHEMBL259181 | — | IC50 | = | 1861.6 | nM | 5.73 |
| CHEMBL573107 | — | IC50 | = | 2483.93 | nM | 5.61 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 2512.62 | nM | 5.60 |
| CHEMBL2363137 | — | IC50 | = | 2588.53 | nM | 5.59 |
| CHEMBL3349342 | — | IC50 | = | 3352.96 | nM | 5.47 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 3456.26 | nM | 5.46 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3475.69 | nM | 5.46 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4131.39 | nM | 5.38 |