Assay Detail
Functional
CHEMBL2363288
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SANGER: Inhibition of human HSC-3 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HSC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.84 | 9.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.88 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.10 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.72 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.52 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.52 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.36 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.25 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.19 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.03 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.95 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.87 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.41 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.33 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.13 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.12 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.87 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.67 |
| CHEMBL217354 | — | — | 1 | 6.54 |
| CHEMBL3349342 | — | — | 1 | 6.51 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.47 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.40 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.37 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.31 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.31 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.17 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.16 |
| CHEMBL585951 | — | — | 1 | 6.15 |
| CHEMBL573107 | — | — | 1 | 6.09 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1315 | nM | 9.88 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.7862 | nM | 9.10 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.015 | nM | 8.52 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 3.015 | nM | 8.52 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.389 | nM | 8.36 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.619 | nM | 8.25 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 6.414 | nM | 8.19 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 9.287 | nM | 8.03 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 11.26 | nM | 7.95 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 12.21 | nM | 7.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 13.55 | nM | 7.87 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 38.69 | nM | 7.41 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 46.82 | nM | 7.33 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 74.53 | nM | 7.13 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 75.54 | nM | 7.12 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 134.61 | nM | 6.87 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 211.98 | nM | 6.67 |
| CHEMBL217354 | — | IC50 | = | 286.45 | nM | 6.54 |
| CHEMBL3349342 | — | IC50 | = | 307.05 | nM | 6.51 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 336.66 | nM | 6.47 |
| CHEMBL803 | CYTARABINE | IC50 | = | 399.94 | nM | 6.40 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 429.08 | nM | 6.37 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 492.3 | nM | 6.31 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 486.26 | nM | 6.31 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 668.43 | nM | 6.17 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 688.29 | nM | 6.16 |
| CHEMBL585951 | — | IC50 | = | 713.18 | nM | 6.15 |
| CHEMBL573107 | — | IC50 | = | 817.69 | nM | 6.09 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 839.54 | nM | 6.08 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 966.48 | nM | 6.01 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1117.83 | nM | 5.95 |
| CHEMBL379975 | — | IC50 | = | 1176.12 | nM | 5.93 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1188.23 | nM | 5.92 |
| CHEMBL577784 | BX-795 | IC50 | = | 1442.08 | nM | 5.84 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1435.89 | nM | 5.84 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1543.8 | nM | 5.81 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1816.75 | nM | 5.74 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1963.65 | nM | 5.71 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2445.09 | nM | 5.61 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL2363137 | — | IC50 | = | 2891.6 | nM | 5.54 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3231.51 | nM | 5.49 |
| CHEMBL202721 | — | IC50 | = | 3368.09 | nM | 5.47 |
| CHEMBL259181 | — | IC50 | = | 3882.22 | nM | 5.41 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 4499.33 | nM | 5.35 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 6173.96 | nM | 5.21 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 8070.68 | nM | 5.09 |
| CHEMBL399530 | — | IC50 | = | 9170.53 | nM | 5.04 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10283.33 | nM | 4.99 |