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Assay Detail

CHEMBL2363313

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Functional
SANGER: Inhibition of human IST-MEL1 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type IST-MEL1
Confidence 1 — Organism
Curated By Autocuration

Target

IST-MEL1 (CHEMBL2366094) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.70 10.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.14
CHEMBL109480 TANESPIMYCIN 3.0 1 9.39
CHEMBL96926 THAPSIGARGIN — 1 9.10
CHEMBL325041 BORTEZOMIB 3.0 1 9.04
CHEMBL105 MITOMYCIN 4.0 1 8.77
CHEMBL3545252 DOCETAXEL 4.0 1 8.65
CHEMBL65 CAMPTOTHECIN -1.0 1 8.42
CHEMBL94657 PATUPILONE 3.0 1 8.39
CHEMBL159 VINBLASTINE 4.0 1 8.34
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 8.09
CHEMBL252164 LUMINESPIB 2.0 1 8.07
CHEMBL1972860 ELESCLOMOL 3.0 1 7.95
CHEMBL1256459 TORIN1 — 1 7.75
CHEMBL1879463 DACTOLISIB 3.0 1 7.73
CHEMBL428647 PACLITAXEL 4.0 1 7.58
CHEMBL514499 GW843682X — 1 7.54
CHEMBL513909 BI-2536 2.0 1 7.35
CHEMBL53463 DOXORUBICIN 4.0 1 7.35
CHEMBL413 SIROLIMUS 4.0 1 6.91
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.91
CHEMBL300389 — — 1 6.90
CHEMBL34259 METHOTREXATE 4.0 1 6.90
CHEMBL5416410 DASATINIB 4.0 1 6.87
CHEMBL553025 VINORELBINE 4.0 1 6.81
CHEMBL603469 LESTAURTINIB 3.0 1 6.71
CHEMBL2144069 — — 1 6.69
CHEMBL2041933 AZD-7762 1.0 1 6.65
CHEMBL217354 — — 1 6.64
CHEMBL6067492 BLEOMYCIN 4.0 1 6.55
CHEMBL803 CYTARABINE 4.0 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.07259 nM 10.14
CHEMBL109480 TANESPIMYCIN IC50 = 0.4075 nM 9.39
CHEMBL96926 THAPSIGARGIN IC50 = 0.7876 nM 9.10
CHEMBL325041 BORTEZOMIB IC50 = 0.9171 nM 9.04
CHEMBL105 MITOMYCIN IC50 = 1.684 nM 8.77
CHEMBL3545252 DOCETAXEL IC50 = 2.254 nM 8.65
CHEMBL65 CAMPTOTHECIN IC50 = 3.81 nM 8.42
CHEMBL94657 PATUPILONE IC50 = 4.064 nM 8.39
CHEMBL159 VINBLASTINE IC50 = 4.526 nM 8.34
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 8.179 nM 8.09
CHEMBL252164 LUMINESPIB IC50 = 8.521 nM 8.07
CHEMBL1972860 ELESCLOMOL IC50 = 11.34 nM 7.95
CHEMBL1256459 TORIN1 IC50 = 17.74 nM 7.75
CHEMBL1879463 DACTOLISIB IC50 = 18.77 nM 7.73
CHEMBL428647 PACLITAXEL IC50 = 26.23 nM 7.58
CHEMBL514499 GW843682X IC50 = 28.8 nM 7.54
CHEMBL53463 DOXORUBICIN IC50 = 44.84 nM 7.35
CHEMBL513909 BI-2536 IC50 = 44.42 nM 7.35
CHEMBL413 SIROLIMUS IC50 = 122.38 nM 6.91
CHEMBL1201182 TEMSIROLIMUS IC50 = 123.2 nM 6.91
CHEMBL34259 METHOTREXATE IC50 = 126.38 nM 6.90
CHEMBL300389 — IC50 = 125.57 nM 6.90
CHEMBL5416410 DASATINIB IC50 = 134.5 nM 6.87
CHEMBL553025 VINORELBINE IC50 = 155.89 nM 6.81
CHEMBL603469 LESTAURTINIB IC50 = 195.57 nM 6.71
CHEMBL2144069 — IC50 = 204.13 nM 6.69
CHEMBL2041933 AZD-7762 IC50 = 225.7 nM 6.65
CHEMBL217354 — IC50 = 227.89 nM 6.64
CHEMBL6067492 BLEOMYCIN IC50 = 279.75 nM 6.55
CHEMBL803 CYTARABINE IC50 = 380.8 nM 6.42
CHEMBL449158 BRYOSTATIN 1 IC50 = 408.56 nM 6.39
CHEMBL379300 A-443654 IC50 = 446.62 nM 6.35
CHEMBL507361 MIRDAMETINIB IC50 = 693.88 nM 6.16
CHEMBL197603 — IC50 = 837.94 nM 6.08
CHEMBL1171837 PONATINIB IC50 = 857.32 nM 6.07
CHEMBL585951 — IC50 = 893.61 nM 6.05
CHEMBL27759 ENTINOSTAT IC50 = 1176.59 nM 5.93
CHEMBL1801204 AZD-8055 IC50 = 1190.82 nM 5.92
CHEMBL3349342 — IC50 = 1892.8 nM 5.72
CHEMBL608533 MIDOSTAURIN IC50 = 2218.3 nM 5.65
CHEMBL379975 — IC50 = 2234.42 nM 5.65
CHEMBL2165191 AZD-6482 IC50 = 2522.86 nM 5.60
CHEMBL289228 TIPIFARNIB IC50 = 2816.22 nM 5.55
CHEMBL44657 ETOPOSIDE IC50 = 2999.43 nM 5.52
CHEMBL36 PYRIMETHAMINE IC50 = 4332.89 nM 5.36
CHEMBL188678 — IC50 = 4582.63 nM 5.34
CHEMBL1190711 — IC50 = 4611.22 nM 5.34
CHEMBL401930 — IC50 = 4597.07 nM 5.34
CHEMBL575448 BMS-754807 IC50 = 5632.47 nM 5.25
CHEMBL591429 PAC-1 IC50 = 6374.32 nM 5.20