Assay Detail
Functional
CHEMBL2363357
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SANGER: Inhibition of human KYSE-270 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-270 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.91 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.35 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.20 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.83 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.56 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.50 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.14 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.02 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.97 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.53 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.43 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.28 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.99 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.88 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.78 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.78 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.66 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.66 |
| CHEMBL585951 | — | — | 1 | 6.65 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.64 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.64 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.59 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.41 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.30 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.14 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.09 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.09 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.07 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.4449 | nM | 9.35 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.6341 | nM | 9.20 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.488 | nM | 8.83 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.776 | nM | 8.56 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.156 | nM | 8.50 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.223 | nM | 8.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.211 | nM | 8.14 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.632 | nM | 8.02 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.59 | nM | 7.97 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 29.76 | nM | 7.53 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 37.09 | nM | 7.43 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 52.11 | nM | 7.28 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 102.84 | nM | 6.99 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 130.88 | nM | 6.88 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 167.78 | nM | 6.78 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 164.28 | nM | 6.78 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 216.69 | nM | 6.66 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 216.92 | nM | 6.66 |
| CHEMBL585951 | — | IC50 | = | 221.63 | nM | 6.65 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 226.33 | nM | 6.64 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 230.84 | nM | 6.64 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 251.88 | nM | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 255.82 | nM | 6.59 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 391.55 | nM | 6.41 |
| CHEMBL939 | GEFITINIB | IC50 | = | 498.65 | nM | 6.30 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 716.9 | nM | 6.14 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 809.89 | nM | 6.09 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 805.29 | nM | 6.09 |
| CHEMBL803 | CYTARABINE | IC50 | = | 848.68 | nM | 6.07 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1047.14 | nM | 5.98 |
| CHEMBL217354 | — | IC50 | = | 1075.77 | nM | 5.97 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1297.34 | nM | 5.89 |
| CHEMBL1190711 | — | IC50 | = | 1450.03 | nM | 5.84 |
| CHEMBL379975 | — | IC50 | = | 1483.26 | nM | 5.83 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1574.23 | nM | 5.80 |
| CHEMBL259181 | — | IC50 | = | 1764.85 | nM | 5.75 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 2027.32 | nM | 5.69 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 2413.55 | nM | 5.62 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2458.61 | nM | 5.61 |
| CHEMBL2363137 | — | IC50 | = | 3031.83 | nM | 5.52 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4651.26 | nM | 5.33 |
| CHEMBL573107 | — | IC50 | = | 5535.36 | nM | 5.26 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5660.31 | nM | 5.25 |
| CHEMBL577784 | BX-795 | IC50 | = | 5775.93 | nM | 5.24 |
| CHEMBL191384 | — | IC50 | = | 5966.06 | nM | 5.22 |
| CHEMBL258844 | — | IC50 | = | 6756.15 | nM | 5.17 |
| CHEMBL393929 | — | IC50 | = | 7038.72 | nM | 5.15 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 7383.66 | nM | 5.13 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 8585.36 | nM | 5.07 |
| CHEMBL221137 | EMBELIN | IC50 | = | 8855.71 | nM | 5.05 |