Assay Detail
Functional
CHEMBL2363358
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SANGER: Inhibition of human KYSE-410 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-410 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.71 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.92 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.99 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.91 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.21 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.03 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.80 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.32 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.25 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.23 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.99 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.74 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.52 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.50 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.23 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.12 |
| CHEMBL217354 | — | — | 1 | 6.06 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.99 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.93 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.90 |
| CHEMBL585951 | — | — | 1 | 5.89 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.85 |
| CHEMBL379975 | — | — | 1 | 5.81 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.80 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.78 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.73 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.66 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1212 | nM | 9.92 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.023 | nM | 8.99 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.235 | nM | 8.91 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.213 | nM | 8.21 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.297 | nM | 8.03 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 15.86 | nM | 7.80 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 47.72 | nM | 7.32 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 55.87 | nM | 7.25 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 59.47 | nM | 7.23 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 78.11 | nM | 7.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 97.97 | nM | 7.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 103.46 | nM | 6.99 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 180.4 | nM | 6.74 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 301.2 | nM | 6.52 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 312.54 | nM | 6.50 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 583.59 | nM | 6.23 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 752.42 | nM | 6.12 |
| CHEMBL217354 | — | IC50 | = | 877.18 | nM | 6.06 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1035.2 | nM | 5.99 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1180.52 | nM | 5.93 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1270.14 | nM | 5.90 |
| CHEMBL585951 | — | IC50 | = | 1278.72 | nM | 5.89 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1413.19 | nM | 5.85 |
| CHEMBL379975 | — | IC50 | = | 1556.57 | nM | 5.81 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1566.5 | nM | 5.80 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1656.72 | nM | 5.78 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1854.55 | nM | 5.73 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2191.94 | nM | 5.66 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2565.17 | nM | 5.59 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3362.87 | nM | 5.47 |
| CHEMBL3349342 | — | IC50 | = | 3347.33 | nM | 5.47 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3500.7 | nM | 5.46 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3639.26 | nM | 5.44 |
| CHEMBL188678 | — | IC50 | = | 5476.36 | nM | 5.26 |
| CHEMBL2363137 | — | IC50 | = | 5825.82 | nM | 5.24 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6378.32 | nM | 5.20 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 6306.45 | nM | 5.20 |
| CHEMBL577784 | BX-795 | IC50 | = | 6713.45 | nM | 5.17 |
| CHEMBL259181 | — | IC50 | = | 6972.3 | nM | 5.16 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 7279.24 | nM | 5.14 |
| CHEMBL1190711 | — | IC50 | = | 7222.99 | nM | 5.14 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 8146.5 | nM | 5.09 |
| CHEMBL573107 | — | IC50 | = | 10061.47 | nM | 5.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 12845.57 | nM | 4.89 |
| CHEMBL399530 | — | IC50 | = | 13458.23 | nM | 4.87 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 16028.96 | nM | 4.79 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 16591.01 | nM | 4.78 |
| CHEMBL105442 | CI-1040 | IC50 | = | 18457.74 | nM | 4.73 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 19913.94 | nM | 4.70 |