Assay Detail
Functional
CHEMBL2363363
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SANGER: Inhibition of human L-363 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | L-363 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.90 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 9.62 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.08 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.73 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.55 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.43 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.22 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.11 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.97 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.91 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.91 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.87 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.85 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.33 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.16 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.13 |
| CHEMBL514499 | GW843682X | — | 1 | 7.09 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.09 |
| CHEMBL300389 | — | — | 1 | 7.03 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.02 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.96 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.94 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.83 |
| CHEMBL379300 | A-443654 | — | 1 | 6.82 |
| CHEMBL512504 | — | — | 1 | 6.67 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.49 |
| CHEMBL401930 | — | — | 1 | 6.48 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.41 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 0.242 | nM | 9.62 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.8325 | nM | 9.08 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.869 | nM | 8.73 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 2.835 | nM | 8.55 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.879 | nM | 8.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.997 | nM | 8.22 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 7.701 | nM | 8.11 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 10.69 | nM | 7.97 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 12.27 | nM | 7.91 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.38 | nM | 7.91 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 13.51 | nM | 7.87 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 14.26 | nM | 7.85 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 44.73 | nM | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 46.79 | nM | 7.33 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 69.01 | nM | 7.16 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 73.9 | nM | 7.13 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 82.06 | nM | 7.09 |
| CHEMBL514499 | GW843682X | IC50 | = | 81.18 | nM | 7.09 |
| CHEMBL300389 | — | IC50 | = | 92.63 | nM | 7.03 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL513909 | BI-2536 | IC50 | = | 110.79 | nM | 6.96 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 115.82 | nM | 6.94 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 146.78 | nM | 6.83 |
| CHEMBL379300 | A-443654 | IC50 | = | 153.11 | nM | 6.82 |
| CHEMBL512504 | — | IC50 | = | 211.21 | nM | 6.67 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 324.43 | nM | 6.49 |
| CHEMBL401930 | — | IC50 | = | 328.28 | nM | 6.48 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 387.03 | nM | 6.41 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 390.26 | nM | 6.41 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 434.17 | nM | 6.36 |
| CHEMBL585951 | — | IC50 | = | 445.08 | nM | 6.35 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 503.1 | nM | 6.30 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 566.57 | nM | 6.25 |
| CHEMBL939 | GEFITINIB | IC50 | = | 671.94 | nM | 6.17 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 798.42 | nM | 6.10 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 834.42 | nM | 6.08 |
| CHEMBL509032 | TAE-684 | IC50 | = | 823.75 | nM | 6.08 |
| CHEMBL577784 | BX-795 | IC50 | = | 1181.97 | nM | 5.93 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1342.08 | nM | 5.87 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1339.29 | nM | 5.87 |
| CHEMBL379975 | — | IC50 | = | 1531.38 | nM | 5.82 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1727.06 | nM | 5.76 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1874.12 | nM | 5.73 |
| CHEMBL202721 | — | IC50 | = | 1951.2 | nM | 5.71 |
| CHEMBL38 | TRETINOIN | IC50 | = | 2069.64 | nM | 5.68 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 2280.61 | nM | 5.64 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2435.07 | nM | 5.61 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2743.7 | nM | 5.56 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 2922.12 | nM | 5.53 |